Saturday, March 24, 2007

a Minor Groove Binder

the internet certainly is fascinating. (maybe not as much as the inner nut, that guy who's running loose in my head.) I went to my google page and let my hands fall freely on the keyboard without looking. this what I got: ]mermgb...so I googled it. sure enough it turns out to be something:

A method for detecting a target sequence in a polynucleotide,wherein the polynucleotide is present in a mixture comprising a plurality of polynucleotides that do not contain the target sequence, and wherein the target sequence differs by only a single nucleotide from one or more sequences in thenon-target polynucleotides, the method comprising:(a) providing a Minor Groove Binder (MGB)-oligonucleotide conjugate, wherein the sequence of the oligonucleotide is perfectly complementary to the target sequence;(b) incubating the MGB-oligonucleotide conjugate and the mixture under hybridization conditions; and(c) detecting polynucleotides which preferentially hybridize to the MGB-oligonucleotide conjugate, whereby a polynucleotide which preferentially hybridizes to the MGB-oligonucleotide conjugate contains the target sequence.

a minor groove binder...how about that,
you learn something new every day.

4 comments:

  1. I believe you have a song title.

    Or a band name: Adrian Belew and the Minor Groove Binders.

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  2. This comment has been removed by the author.

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  3. Brilliant discovery! Probably the only possible combination of letters that doesn't return something pornographic....

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  4. The longer you typed, the better you got into it.
    This is "A Minor Groove Binder" place!
    ozzie

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